To create some of the most important Arcana cards and enchantments, you'll need Pearls in Hades 2. However, like any other item, you will have to jump through several hoops before obtaining this resource. If it gets Melinoe one step closer to beating Chronos, I guess there's no harm in grinding for Pearls. That said, find out how to obtain and use this material for yourself.
To get Pearls in Hades 2, you must beat the boss battle between Scylla and the Sirens. This battle takes place at the end of the Oceanus biome, the second area in the game. To reach the Oceanus biome, you must first go through the Erebus (first area) and beat Headmistress Hecate's boss fight. After you do this, you will be teleported to Oceanus.
One thing you need to know about Oceanus is that it is full of environmental traps. From hot and harmful steam to boilers, there are several traps to avoid. Once you get to Oceanus, just follow the storyline and eventually you will encounter Scylla and Sirens there.
Unfortunately, there's no other way to get pearls in Hades 2. So every time you want a pearl, you have to start over, defeat Scylla and Sirens, and then collect them.